Parkinson Disease A Progressive Disorder - 4669 Words

2.1 Overview The most frequent neurodegenerative movement disorder today is Parkinson Disease (Barth et al., 2011), with a prevalence which increases with age – from 0.01% of people in the age group 40 to 44 years, increasing steadily to approximately 1% at age 65 and 22% at age 85 or over. Due to an aging society, increasing industrialization and environmental factors, the number of patients will grow rapidly in the forthcoming decades. Parkinson’s disease (PD) is a progressive disorder of unknown etiology that has no cure. It is characterized by bradykinesia, rest tremor, cogwheel rigidity and postural instability, along with a number of non-motor signs. The neurochemical hallmark of PD is dopamine loss in the nigrostriatal dopamine system (Adler, 2011). In the substantia nigra (SN) of people with PD there is a loss of neuronal cells, demonstrated by the degeneration of brainstem nuclei (Brooks, 1998). This typically shows as Lewy bodies – spherical masses of protein that develop inside nerve cells. However the progression of neuronal loss is quite variable in different PD patients and at different phases of the disease. At present there is no treatment that affects the degeneration, for example by slowing the rate of cell death or by protecting neurons. Unfortunately by the time that PD is first diagnosed, 60% to 70% of the neurons in the SN responsible for dopamine have degenerated and the striatal dopamine content is reduced by 80% (Adler, 2011) and neuroprotectiveShow MoreRelatedParkinson s Disease : A Progressive Disorder1751 Words   |  8 PagesEach year more than 60,000 Americans are diagnosed with Parkinson’s disease (PDF, 2014). That sixty thousand does not include the many thousand cases that go undetected each year. Parkinson’s is a progressive disorder that occurs in the nervous system. This disease affects a person’s movement. Parkinson’s disease develops progressively. The most common first sign of Parkinson’s is slight shaking of a body part. In the initial phase of Parkinson’s a person will experience slurring of speech and anRead MoreParkinson Disease : A Progressive Disorder That Affects The Nervous System2652 Words   |  11 PagesParkinson disease is known as a progress ive disorder that affects the nervous system. Some of the main symptoms of the disorder include tremor, muscular rigidity and slow imprecise movement. On the other hand Alzheimer s disease is the most common cause of dementia. The disorder includes memory loss along with difficulties with thinking, problem-solving or language. Both Alzheimer’s and Parkinson’s have many similarities but evidence may suggest they are separate disorders. Both Parkinson’s andRead MoreParkinson s Disease Is A Chronic Progressive Movement Disorder Of The Central Nervous System895 Words   |  4 PagesParkinson s disease is a chronic progressive movement disorder of the central nervous system. Early in the course of the disease, the most obvious symptoms are movement-related; these include shaking, rigidity, slowness of movement and difficulty with walking and Parkinson’s like gait (leaning forward, small fast pace steps, shuffling, etc.). Parkinson’s involves the malfunction and death of nerve cells in the brain, entitled neurons. Although damage can be spread about, it primarily affects neuronsRead MoreThe Purpose Of My Research Conducted For This Paper Was1677 Words   |  7 PagesThe purpose of my research conducted for this paper was to examine the relationship between Parkinson s disorde r and its connection to the anatomy of the human body. Parkinson s is a progressive disorder of the nervous system that affects movement due to the loss of Dopamine. Dopamine which is a neurotransmitter located in the brain allows signals to be transported from one nerve cell to another. Its purpose is to regulate both movement and cognition. The loss of these chemical messengers can causeRead MoreThe Disease Of Parkinson s Disease1648 Words   |  7 PagesParkinson’s disease has been cataloged as one of the most serious and slowly progressive neurodegenerative disease that affects a wide array of motor and non-motor aspects that impact the function of a person. Afflicting over four million Americans and the second most common neurological disorder after Alzheimer’s disease, Parkinson’s continues to take its toll on the neurological health of many(Constantinescu et al, 2007 ). James Parkinson, a British physician first coined this disorder as â€Å"shakyRead M oreIdiopathic Parkisons Disease779 Words   |  3 PagesPARKINSONS DISEASE Parkinson also known as idiopathic Parkinson basically targets dopamine in brain nerve cells specially in mid brain and substantia nigra causes cell death. In Parkinson disorder levels of dopamine are decreased in brain. In early stage of Parkinson signs are very oblivious which includes tremors (shaking of hands), muscle rigidity and slowness of movement. Treatment can relief the symptoms but do not cure the disease. CLASSIFICATION: 1. IDIOPATHIC PARKINSONS DISEASE: In thisRead MoreParkinson’s Disease Essay1446 Words   |  6 PagesParkinson’s Disease is known as one of the most common progressive and chronic neurodegenerative disorders. It belongs to a group of conditions known as movement disorders. Parkinson disease is a component of hypokinetic disorder because it causes a decreased in bodily movement. It affects people who are usually over the age of 50. It can impair an individual motor as well as non-motor function. Some of the primary symptoms of Parkinson’s disease are characterized by tremors or trembling in handsRead MoreParkinson s No Longer Happens But Is Inherited1181 Words   |  5 Pagesone inherits a trait, disorder, or disease that is passed or shared through families. Whether it is albinism or red hair (also referred to as day walkers or ginger) height or heath both parent carry the autosomal trait that is passed to the child. An autosomal recessive disorder means that two copies of an abnormal gene must be present in order for the disease or trait to develop. A mutation in a gene on one of the first 22 non-sex chromosomes can lead to an autosomal disorder like Down syndrome orRead MoreIs Parkinson Disease A Disease?1290 Words   |  6 Pages Parkinson Disease Danielle West University Of Arkansas Fort Smith Medical Terminology Fall of 2015 Introduction Parkinson is a disease that is a glitch in the neurons in the brain, which frequently affects the substantia nigra. Part of the dying neurons produces a chemical called dopamine. As this progresses, the dopamine in the brain decreases. Dopamine is a chemical in the brain which helps the body regulate coordination and movement in the body. Once Parkinson Disease (PD)Read MoreUnderstanding Of Parkinson s Disease1527 Words   |  7 PagesUnderstanding Parkinson’s disease Many disease have been discovered thought the years. Many of which target a specific sex, age, or even a specific gene in a body. One particular disease is Parkinson’s disease that targets adults of age 60 and over. In 1817 James Parkinson wrote his famous essay over Shanking Paisy. Making James Parkinson the first to describe paralysis agitans that will later be named Parkinson’s disease. James Parkinson was born in the year 1755 Landon, England and would also